[3] On 23 May 1948, the governing board of APOEL football club sent a telegram to the Hellenic Association of Amateur Athletics (Greek: Σ.Ε.Γ.Α.Σ.

Club players considering this action as a specifically political comment on the Greek Civil War distanced themselves from the board and were duly expelled from APOEL.

Along with other left-wing teams such as Nea Salamina, Alki Larnaca and Orfeas Nicosia, Omonia helped create the Cyprus Amateur Football Federation in December 1948.

After joining the Cypriot First Division in 1953, Omonia only placed seventh out of nine teams in the 1953–54 season, barely avoiding relegation.

The 1980s was a successful decade for the club as it won an additional seven Cypriot League Championship titles including another five consecutive in 1981, 1982, 1983, 1984, 1985, and in 1987 and in 1989.

After numerous seasons of poor signings and underachieving, Omonia's reigns would be taken over by new chairman and team president, Miltiadis Neophytou in 2008.

The team would soon be put back on track starting in 2006, beginning with the signing of Cyprus international goalkeeper Antonis Georgallides.

Omonia would continue its star-studded signings by acquiring Cypriot stars that had been playing abroad, such as Elias Charalambous and Stathis Aloneftis.

Omonia would then make headlines with the shocking signing of all-time leading scorer for Cyprus, Michalis Konstantinou.

En route, Omonia would also acquire young Cypriot hopefuls, 21-year-old Dimitris Christofi and 20-year-old Georgios Efrem.

Efrem, who had been playing on the youth team of Arsenal and later Scottish side Rangers, would be the final piece to the puzzle needed to win its 20th Cypriot league championship.

During the 2009–10 season, led by the new captain, Elias Charalambous, Omonia would not lose a single derby, including play-off matches against APOEL, Anorthosis and Apollon.

Omonia would not be able to repeat as Champion during the 2010–11 regular season, and instead had to settle with finishing second,[11] despite the addition of yet another young Cypriot rising star, Andreas Avraam.

[12] The following season, Omonia won their 14th cup starring André Alves, who scored the winning goal against AEL Limassol in the final.

In May 2018, a general assembly was called and members voted to hand the football department over to Stavros Papastavrou, an American-based Cypriot businessman.

[31][32] He has stated that he will provide funds for the development of the club's academies and training grounds, and that the potential creation of a new stadium will be considered.

The following season, a penalty shootout win over Red Star Belgrade meant that the club had qualified for the group stage of a European Competition for the first time in its history.

[43][44] A turbulent 2023–24 campaign, which included the hiring and firing of a sporting director and the sacking of two coaches, concluded without domestic or European success for Omonia.

Giannis Anastasiou and Valdas Dambrauskas were appointed as football advisor and head coach ahead of the 2024–25 season, respectively.

OFC TV is the most subscribed YouTube channel for a sports team in Cyprus, and features content such as match highlights, training sessions, and press conferences.

In 2003, the club purchased a piece of land in Nicosia with the aim of building a stadium, however the property was given to the Bank of Cyprus due to debts of the owner company.

[50] In August 2024, having previously spoken about his intention to do so,[51] Omonia FC owner Stavros Papastavrou announced that a new privately owned stadium will be built for the club.

The stadium will be located in Tseri, it will have a capacity of 16,000 seats, is expected to be ready for use in the 2028–29 season and along with surrounding premises will cost approximately 60-70 million Euros.

A 2022 study conducted by the University of Nicosia found Omonia to be the most popular team on the island by far, with 30.7% of the approximately 1500 contestants stating they support the club.

[54][55] Omonia supporters are known for their left-leaning, socialist character, with many stating that they associate themselves with the Progressive Party of Working People.

[56] By the end of February 2013, Omonia was struggling to meet the UEFA criteria due to the economic crisis that had engulfed the club.

Hundreds of events were organised island wide with the motto; "ΕΙΜΑΙ ΟΜΟΝΟΙΑ ΔΗΛΩΝΩ ΠΑΡΩΝ" meaning, "I'M WITH OMONIA, I DECLARE MYSELF PRESENT.

[citation needed] On 29 May 2018, the club agreed to turn its football department into a for-profit company, under the ownership of Stavros Papastavrou.

[60][61] On the same day, Gate 9 declared they would no longer support the team, and announced they would create their own football club, which would "respect the principles and history of Omonia".