As of 2022[update], Oneonta Senior High School had 477 students, of whom 20.4% were minority and 35% were economically disadvantaged.

[7] In 1913 at the school's 42nd commencement 53 students graduated, its largest class up to that point.

[12] In the 1990s, the high school was renovated and a science wing added.

[14] Oneonta Senior High School is a member of the Southern Tier Athletic Conference (STAC).

[1] They are also part of the New York Public High School Athletic Association (NYPSAA) under Section IV, Class C.[2] Oneonta's mascot is a Yellowjacket, taking inspiration from the Georgia Tech Yellowjackets.