From Florence, it ran west-southwest to Sumter, which was a hub for the company and a connection with some of their other lines.

[2] From Sumter, the line continued southwest to Denmark and Cope before coming to an end at Robbins (just east of Augusta, Georgia), where it connected with the Charleston and Western Carolina Railway (an Atlantic Coast Line subsidiary).

[4] The C&WC was owned by the Atlantic Coast Line Railroad and operated as a subsidiary.

Local freight trains ran the Creston Branch six days a week at this time as well.

[2] In 1959, the Atlantic Coast Line Railroad fully merged the Charleston and Western Carolina Railway into its network.

[7] In 1980, the Seaboard Coast Line's parent company merged with the Chessie System, creating the CSX Corporation.

In the 1980s, CSX abandoned the line at the south end from just north of Robbins to Cope.

[8] Further north, CSX abandoned the line from Timmonsville to Lynchburg in 1989, which severed it as a through route from Florence to Sumter.