Orfana railway station (Greek: Σιδηροδρομικός Σταθμός Ορφανών, romanized: Sidirodromikos stathmos Orfanon) is a railway station in Orfana, Karditsa, Thessaly, Greece.

On 16 January 1972, at around 1645 hours[3] on the line between Orfana and Doxara, a breakdown in communication between the corresponding stationmasters at Doxaras and Orfana caused an express train and a military relief train to collide in bad weather on the single track line.

The southbound diesel hauled Acropolis Express and northbound Number 121 Athens-Thessaloniki, (known as posta) were allowed to proceed[4] without first allowing a passing loop.

21 people died, and more than 40 were injured[5] in one of the deadliest rail accidents in Greece.

[6][3] Nikolaos Gekas[5] The stationmaster at Orfana was later sentenced to 5 years for his part in the disaster.