Orthogonal ligand-protein pair

This causes a cascade that leads to the activation of the slow anion channel 1 and closing of the leaf guard cells and stomata.

The natural response by the plant using abscisic acid to bind PYR1 in drought conditions is not strong enough and is activated too late to significantly hinder crop yield loss.

Abscisic acid is also currently too expensive to synthesize to be used as a spray to control drought response artificially on a mass scale.

TRβ histidine 435 is a T3 insensitive mutant that plays a role in human pituitary cancer and RTH.

Selectively altering the ligand-binding domain to make it orthogonal to the natural ligand-receptor interface, as well as the making the DNA-binding domain and hormone response element orthogonal, would give a researcher precise control of a gene's transcription in order to study a gene's action.