[5] Common side effects include numbness, feeling tired, nausea, diarrhea, and low blood cell counts.

[16] When compared with just 5-fluorouracil and folinic acid administered according to the de Gramont regimen, a FOLFOX4 regime produced no significant increase in overall survival, but did produce an improvement in progression-free survival, the primary end-point of the phase III randomized trial.

[17] Side-effects of oxaliplatin treatment can potentially include: In addition, some patients may experience an allergic reaction to platinum-containing drugs.

[24] According to in vivo studies, oxaliplatin fights carcinoma of the colon through non-targeted cytotoxic effects.

Like other platinum compounds, its cytotoxicity is thought to result from inhibition of DNA synthesis in cells.

[32] Exclusivity code I-441, which expired on 4 November 2007, is for use combination with infusional 5-FU/LV for adjuvant treatment stage III colon cancer patients who have undergone complete resection primary tumor-based on improvement in disease free survival with no demonstrated benefit overall survival after 4 years.