The boys' soccer team won three consecutive state championships from 2001 to 2003, losing only 1 game in 2002 and going undefeated in 2003.

In the 2010 season, the girls' volleyball team went undefeated, winning the Division II state championship, and the boys' cross-country and indoor track teams won the newly created Division II championships.

In 2015, the boys' soccer team defeated Portsmouth High School to win the Division II championship.

Previously led by Suzanne Filippone, who assumed the role before the 2016–17 school year and until 2021 when she was nominated Assistant Superintendent for ORCSD.

For the previous three years, Filippone had been Assistant Principal at Spaulding High School in Rochester, New Hampshire, and was hired after the previous ORHS principal, Todd Allen, accepted the position of Assistant Superintendent of Oyster River Cooperative School District.