p-Phenetidine (4-ethoxyaniline) is a chemical compound with the molecular formula C8H11NO.

It is used as an intermediate in the synthesis of pharmaceutical drugs, dyes, and the sweetener dulcin.

[1] p-Phenetidine is a metabolite of the pharmaceutical drugs bucetin and phenacetin[3] and of the preservative ethoxyquin.

[4] It is also used as a chemical intermediate in the manufacture of bucetin, phenacetin, ethoxyquin, and phenacaine.

p-Phenetidine has high renal toxicity[3] and it is believed to be responsible for the adverse effects that led to the withdrawal of phenacetin and bucetin from pharmaceutical use.