2AX4906023972ENSG00000198682ENSMUSG00000024899O95340Q5TB52O88428NM_004670NM_001015880NM_001201470NM_011864NM_001360403NP_001015880NP_004661NP_004661.2NP_001188399NP_035994NP_001347332Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 is an enzyme that in humans is encoded by the PAPSS2 gene.

[5][6] Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds.

Two different tissue isoforms encoded by different genes synthesize PAPS.

Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia.

Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.