The PFL 10 mixed martial arts event for the 2021 season of the Professional Fighters League was held on October 27, 2021.

The event also featured five other finals matchups, with the winner of each weight class taking home PFL's trademark $1 million prize.

[4] The five other championship bouts included a welterweight rematch between Ray Cooper III and Magomed Magomedkerimov, Movlid Khaybulaev versus UFC vet Chris Wade at featherweight, a heavyweight rematch between Ante Delija and Bruno Cappelozza, UFC vet Antônio Carlos Júnior taking on Marthin Hamlet at light heavyweight, and Loik Radzhabov rematching Raush Manfio at lightweight.

[5] This PFL event featured the second MMA appearance of boxing champion Claressa Shields.

[7] * Larissa Pacheco was originally scheduled to face Taylor Guardado but was unable to continue in the tournament.