The PFL 1 mixed martial arts event for the 2021 season of the Professional Fighters League was held on April 23, 2021.

This was the first regular season event of the tournament and included fights in the Featherweight and Lightweight divisions.

[3] The remaining two fights of the main card were held in the featherweight division: former two-time PFL Featherweight champion Lance Palmer faced the 2011 NCAA Division I champion Bubba Jenkins and Movlid Khaybulaev was to face Jason Soares.

Akhmet Aliev received a walkover win regardless of bout outcome but is eligible to gain stoppage points.

The fighters who made weight will not receive a walkover, but will earn points and contracted purse amounts based on their performance in the altered matchup.