The PFL 2 mixed martial arts event for the 2021 season of the Professional Fighters League was held on April 29, 2021.

[5] In the co-main event, the 2019 PFL Welterweight tournament winner Ray Cooper III is scheduled to fight Jason Monet.

[9] On March 25, it was announced that Magomed Magomedkerimov and Alexey Kunchenko pulled out of their bouts due to undisclosed reasons.

[11] The next day it was announced that Mozharov pulled out for medical reasons so Jordan Young will receive a walkover win and 3 points.

The fighters who made weight will not receive a walkover, but will earn points and contracted purse amounts based on their performance in the altered matchup.