The PFL 4 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 10, 2021.

Schulte's opponent Raush Manfio - who replaced an injured Mikhail Odintsov- will now face Pettis at PFL 6 on June 25, 2021.

Boxing champion and Olympic gold medalist Claressa Shields made MMA debut on the main card of this event against Brittney Elkin.

[5] Dana White's Contender Series alumni Brendan Loughnane faced The Ultimate Fighter 27 contestant Tyler Diamond to round out the main card.

Their opponents Clay Collard and Sheymon Moraes received a walkover win regardless of bout outcome but are eligible to gain stoppage points.