The PFL 3 mixed martial arts event for the 2021 season of the Professional Fighters League was held on May 6, 2021.

[4] In the co-main event, the 2019 PFL Lightweight champion Kayla Harrison fought Mariana Morais.

However, Willis was pulled from the bout after the weigh-ins due to being not medically cleared and replaced by Muhammed DeReese.

[7] On May 10, the New Jersey State Athletic Control Board announced that Renan Ferreira's TKO win against Fabrício Werdum was overturned to a No contest after they found that referee Keith Peterson missed a pair of taps by Ferreira that were caught on camera as Werdum applied a choke right before he lost by TKO.

The fighters who made weight will not receive a walkover, but will earn points and contracted purse amounts based on their performance in the altered matchup.