The PFL 6 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 25, 2021.

The co-main was to be a bout between 2019 Professional Fighters League season Heavyweight Champion Ali Isaev against Renan Ferreira.

[4] Austin however was pulled from the bout due to unknown reasons and replaced by returning PFL fighter, Carl Seumanutafa.

Schulte's opponent Raush Manfio - who replaced an injured Mikhail Odintsov[8] - faced Pettis at this event.

[9] Movlid Khaybulaev and Lance Palmer were scheduled bouts at PFL 4 against Sheymon Moraes and Jesse Stirn respectively.

The fighters who made weight will not receive a walkover, but will earn points and contracted purse amounts based on their performance in the altered matchup.