[8] The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).

The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML.

[7] Understanding and stimulating the thermogenic processes in brown adipocytes provides possible therapeutic options for treating obesity.

[9] White adipose tissue (WAT) primarily stores excess energy in the form of triglycerides.

These beige cells have a brown adipose tissue-like phenotype and actions, including thermogenic processes seen in BAT.

[7] The study found that the presence of PRDM16 in subcutaneous WAT leads to a significant up-regulation of brown-fat selective genes UCP-1, CIDEA, and PPARGC1A.

[7] This energy expenditure in turn is attributed to PRDM16’s ability to up-regulate UCP-1 and CIDEA gene expression, resulting in thermogenesis.