51422108099ENSG00000106617ENSMUSG00000028944Q9UGJ0Q91WG5NM_001363698NM_001170555NM_001170556NM_145401NM_001310480NP_001350627NP_001164026NP_001164027NP_001297409NP_6633765'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.

AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol.

This gene is a member of the AMPK gamma subunit family and encodes a protein with four CBS domains.

Mutations in this gene have been associated with ventricular pre-excitation (Wolff–Parkinson–White syndrome), progressive conduction system disease and cardiac hypertrophy.

Alternate transcriptional splice variants, encoding different isoforms, have been characterized.