1VD2, 1WMH, 1ZRZ, 3A8W, 3A8X, 3ZH8558418759ENSG00000163558ENSMUSG00000037643P41743Q62074NM_002740NM_008857NP_002731NP_032883Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.

The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes.

This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway.

This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis.

There is a single exon pseudogene mapped on chromosome X.