Sequence database

[3] In 1965 Margaret Dayhoff and her team at the National Biomedical Research Foundation (NBRF) published "The Atlas of Protein Sequence and Structure".

They made use of the newly computerized (1964) Medical Literature Analysis and Retrieval System (MEDLARS) at the National Institutes of Health (NIH).

The team used computers to store the data but had to manually type and proofread each sequence, which had a high cost in time and money.

The National Biomedical Research Foundation (NBRF) was on the cutting edge of utilizing computers for medicine and biology at this time.

Dayhoff and her team made use of their facilities for determining amino acid sequences of protein molecules in mainframe computers.

This led to many developments such as, probabilistic models of amino acid substitutions, sequence aligning and phylogenetic trees of evolutionary relationships of proteins.

[7] The solution towards solving this issue is found by making a variety of scoring systems available to suit to the specific problem.