2LK4, 3CC6, 3ET7, 3FZO, 3FZP, 3FZR, 3FZS, 3FZT, 3GM1, 3GM2, 3GM3, 3H3C, 3U3F, 4EKU, 4H1J, 4H1M, 4R32, 4XEK, 4XEF, 4XEV218519229ENSG00000120899ENSMUSG00000059456Q14289Q9QVP9NM_004103NM_173174NM_173175NM_173176NM_001162365NM_001162366NM_172498NM_001360233NP_004094NP_775266NP_775267NP_775268NP_001155837NP_001155838NP_766086NP_001347162Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.

[5][6] This gene encodes a cytoplasmic protein tyrosine kinase that is involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway.

The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity.

[7] In addition, SOCE-induced Pyk2 activation mediates disassembly of endothelial adherens junctions, via tyrosine (Y1981-residue) phosphorylation of VE-PTP.

[8] This protein has been shown to bind a CRK-associated substrate, a nephrocystin, a GTPase regulator associated with FAK, and the SH2 domain of GRB2.