Packers Run is a tributary of the Susquehanna River in Northumberland County, Pennsylvania, in the United States.

[1] After a few tenths of a mile, the stream turns southwest and then south, leaving Montour Ridge and entering a plain.

[1] Packers Run joins the Susquehanna River 131.62 miles (211.82 km) upstream of its mouth.

[1] Packers Run is located near the Devils Feather Bed, which is a geographical feature on Montour Ridge.

[3] According to staff from the Pennsylvania Fish and Boat Commission, Packers Run was inadvertently left out of the Chapter 93.9 Drainage List, along with several other streams in its vicinity.