The work was commissioned by Marquis Baldassarre Paluzzi Albertoni initially to Giacomo della Porta (1532-1602), then continued and completed by Girolamo Rainaldi (1570-1655), in an area between the buildings De Rossi (later Cavalletti) and Capizucchi.

In 1603, Knight Baldassarre Paluzzi Albertoni requested a permit to build the new facade, widening the area of the existing property towards the square and aligning the new wall with the corner of the adjacent Capizucchi palace.

The restoration of the Palace could not be postponed further since the complex was in a poor state of repair as a result of years of neglect: the works concerned mainly parts of the courtyard, the stairs, and the interiors.

As can be seen from the licenses obtained by the owners respectively 1603 and 1616, the first to redo the aforementioned façade of the palace on Piazza Campitelli,[4] the second to build the overpass connecting the two properties,[5] these did not provide for other demolition and reconstruction works of the structures.

The façade and the external decorations of the Palazzo Grande are by Rainaldi with an exquisitely manneristic invention, while the immediate inheritance received by Della Porta provided for the general form of the compact and traditional construction[6] and generates the orthogonality of the internal entrance gallery.

It is necessary to underline that at the time of planning the facade of the current Church had not yet been built and that the birthplace of Blessed Ludovica Albertoni,[7] the true spiritual authority of the family, was located on the same site.

A part of the perimeter wall of the house of the Blessed is still visible with an ancient fresco inside the Chapel of the Albertoni family in Santa Maria in Campitelli.

[8] Another effect produced is the loss of "orientation" within the two buildings: in fact, visiting the rooms from the inside, it is not fully realized if its position is in the large body of the Palace or in the other smaller, so called Palazzetto.