This was Panama's seventh appearance at the Parapan American Games, having competed at every edition of the games since the inaugural edition in 1999.

Paralympic shooter Arístides Guevara and parathlete Keitly Escobar were the country's flagbearers during the opening ceremony.

[1] The following competitors won medals at the games.

In the discipline sections below, the medalists' names are bolded.

The following is the list of number of competitors (per gender) participating at the games per sport/discipline.