Uruguay is scheduled to compete in the 2023 Parapan American Games in Santiago, Chile from 17 November to 26 November 2023.

This is Uruguay's seventh appearance at the Parapan American Games, having competed at every edition of the games since the inaugural edition in 1999.

Paralympic judoka Henry Borges and para swimmer Hanna Arias were the country's flagbearers during the opening ceremony.

In the discipline sections below, the medalists' names are bolded.

The following is the list of number of competitors (per gender) participating at the games per sport/discipline.