Panama is scheduled to compete at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023.

Baseball player Davis Romero and artistic gymnast Hillary Heron were the country's flagbearers during the opening ceremony.

[1] Meanwhile, karateka Alberto Gálvez and golfer Laura Restrepo were the country's flagbearers during the closing ceremony.

[3] Panama qualified a men's team (of 12 athletes) after finishing 11th at the 2022 FIBA Americup and receiving a reallocated spot.

Panama qualified one female fencer through the 2022 Pan American Fencing Championships in Asuncion, Paraguay.