The 2022 presidential campaign of Panfilo Lacson was announced in a televised launch on September 8, 2021, along with his running mate Tito Sotto.

During the administration of President Joseph Estrada, he was appointed as head of the Presidential Anti-Organized Crime Task Force and eventually as PNP Chief.

During the Second EDSA Revolution, Lacson along with several PNP officers withdrew their support to President Estrada and eventually resigned from his post.

[5] On September 8, 2021, Lacson and Sotto officially launched their presidential and vice-presidential bid in a televised event entitled Ito ang Simula (lit. transl.

The 30-minute event, which was aired on almost all television stations and through the internet, was taped in an undisclosed location with a mixture of both live (composed only of friends of both Lacson and Sotto) and virtual audience.

[6] On March 24, Lacson resigned as chairperson and member of Partido Reporma a few hours before the party's leaders endorsed the presidential bid of Vice President Leni Robredo.

Lacson disclosed that Alvarez's chief of staff requested him for ₱800 million to fund the party's campaign, an amount he was unable to produce.

Former mayor of Quezon City Herbert Bautista of NPC and Senator Sherwin Gatchalian were also part of Lacson's slate but were later removed after joining the UniTeam Alliance.

[19][20] After Lacson's resignation from Reporma, Monsour del Rosario announced his support for Leni Robredo's presidential campaign.