Papyrus 49 (Gregory-Aland), designated by 𝔓49, is an early copy of the New Testament in Greek.

It is a papyrus manuscript of the Epistle to the Ephesians, surviving in a fragmentary condition.

[4][5] According to Kurt Aland, it is one of three early manuscripts with the text of the Epistle to the Ephesians.

The letters are slightly inclined to the right; the writing shows the influence of cursive handwriting.

[2] Bradford Welles remarks that "there is not a single case of difference in the letter shapes in the two papyri".

[11] In Ephesians 4:28, it has the unusual textual reading ταις χερσιν το αγαθον, supported only by

[12] In Ephesians 5:5, it has the textual reading ο εστιν (who is), supported by the manuscripts:

, Sinaiticus, Vaticanus, Augiensis, Boernerianus, Athous Lavrensis, 33, 365, 1175, 1739, 1881, 2464, Old-Latin, Peshitta, Coptic manuscripts (Sahidic and Bohairic); the other reading ος εστιν (who is) is supported by Codex Alexandrinus, Codex Bezae, and manuscripts of the Byzantine textual tradition.

[12] In Ephesians 5:9, it has the textual reading φωτος (light), supported by Codex Sinaiticus, Alexandrinus, Vaticanus, Bezae, Augiensis, Boernerianus, Porphyrianus, minuscule 6, 33, 81, 629, 1175c, 1739, 1881, 2464, some Old-Latin manuscripts, Peshitta and Coptic manuscripts.

[8] It is presently assigned to the third century on palaeographic grounds by the Institute for New Testament Textual Research (INTF).

[4] The text of the codex was published by William Hatch and Bradford Welles in 1958 (editio princeps).

[3] Kurt Aland catalogued the manuscript on the list of the New Testament papyri under the number 49.

[15] This conclusion was confirmed by Bradford Welles, Comfort and Barrett, and other palaeographers.