[4][5][6] He remained the starter for the next two seasons, was voted Penn State Football's Most Valuable Offensive Player in 2019, and was invited to the NFL Scouting Combine a year earlier.

Although rumor said he would jump at this, he declined this chance, and in a press conference with Coach James Franklin announced that he had planned to recommit to Penn State for yet another year.

[9] Freiermuth was selected in the second round (55th overall) of the 2021 NFL draft by the Pittsburgh Steelers to replace tight end Vance McDonald, who retired after the 2020 season.

[12] He signed a four-year rookie contract with Pittsburgh on May 25, 2021, and was assigned number 88, most famously worn by Hall of Fame receiver Lynn Swann.

On November 8, Freiermuth had one of his best game of the season, catching five passes on six targets for 43 yards and scoring two touchdowns as the Steelers defeated the Chicago Bears 29-27.

[17] On January 16, 2022, Freiermuth played in his first post-season game of his career against the Kansas City Chiefs in the AFC Wild Card Round of the 2021 playoffs.

[18] During his rookie season, similar to former Steelers tight end Heath Miller, home crowds began chanting "Muth", an abbreviation of "Freiermuth", when he would gain yardage or score a touchdown.

[24] In the second post season appearance of his professional career, Freiermuth caught five passes on eight targets for 76 yards in the AFC Wild Card Round against the Buffalo Bills.

Replay officials determined the fumble had rolled out of bounds due to the ball making contact with Freiermuth as he exited the field of play, giving possession back to the Steelers.

[28][29] In the final moments of Week 5's loss to the Cowboys, the Steelers needed to score a field goal to tie the game with less than ten seconds remaining.

During the AFC wildcard playoff game against the Baltimore Ravens, Freiermuth made three catches for 15 yards as the Steelers lost 28-14, ending their season.