In 2010, he moved to the La Jolla Institute for Immunology in San Diego as a Professor in the Division of Signaling and Gene Expression.
[2] Hogan's research interests have been focused on the signaling and gene expression pathways that result from calcium entry into cells.
He molecularly cloned the transcription factor NFAT, which is dephosphorylated by the calcium-regulated phosphatase calcineurin,[3] and solved its structure in collaboration with the laboratory of Stephen Harrison at Harvard Medical School.
[11] He has made major contributions to our understanding of the mechanisms and regulation of cellular calcium signaling, particularly modulation of the STIM-ORAI pathway in the context of ER-plasma membrane junctions, which he has investigated using whole-genome screens, super-resolution microscopy and single-molecule tracking.
[17][18] He also showed that BATF transcription factors play an important role in preventing the exhaustion of T cells with Chimeric Antigen Receptors (CAR),[19] and that disruption of the NFAT:AP-1 interaction can be achieved with small molecules and may be a promising therapeutic approach.