In the period drama based on English soldier Richard Sharpe, Payal had played a village girl, the daughter of a revolutionary freedom fighter from Bengal.

She joined Namit Kishore's acting academy, where she met Chandra Sekhar Yeleti who offered her the lead role in his Prayanam, opposite Manchu Manoj.

[6] She signed another Hindi comedy film, Patel Ki Punjabi Shaadi opposite Vir Das, directed by Sanjay Chhel.

[8] On 23 September 2020, Ghosh accused Anurag Kashyap and filed a police complaint for sexually harassing her at Yari Road in Versova, Mumbai in 2013.

[14] After Payal Ghosh gave an un-conditional apology to Richa Chadha for her defamatory remarks, Bombay HC recorded the settlement of the case.