The Pelagonia Statistical Region (Macedonian: Пелагониски Регион) is one of eight statistical regions of North Macedonia.

It is located in southwestern part of the country along the eponymous plain.

Internally, it borders the Southwestern and Vardar statistical regions.

Pelagonia statistical region is divided into 9 municipalities: The population of the Pelagonia Statistical Region is 238,136 citizens, or 11.8% of the population of the Republic of North Macedonia, according to the census of 2002.

The largest ethnic group in the region are Macedonians.