From here, the route heads north on a two-lane undivided road between woods to the west and farm fields to the east.

[2][3] A short distance after beginning, the road crosses into Susquehanna Township in Juniata County and heads into agricultural areas with some homes, curving to the northwest.

Here, PA 104 turns northwest to form a concurrency with US 522 on East Main Street, crossing Middle Creek.

PA 104 runs through open farmland before coming into the residential community of Penns Creek, turning northeast and becoming Centerville Street.

[2][5] At the crossing of the Penns Creek, PA 104 continues into Limestone Township in Union County and heads north, running through more farmland with some woods and homes.