PA 407 is a two-lane road that serves Clarks Green and Waverly in northern Lackawanna County.

The road heads through commercial areas and woods, turning north-northwest and passing under a viaduct carrying I-476 (Pennsylvania Turnpike Northeast Extension).

The route heads into residential areas, becoming the border between the borough of Clarks Summit to the west and South Abington Township to the east.

The route heads through the community of Waverly, where it forms a short 2 block concurrency with PA 632.

The route heads into forested areas of Lackawanna State Park and turns north, coming to an intersection with the western terminus of PA 524.

The route heads through more rural areas and passes through Kochners Corners, becoming Philadelphia-Great Bend Turnpike.