The route is a two-lane undivided road that passes through rural areas of farms and woods in southern Susquehanna County.

PA 374 was created in April 1961 as one of five state highways designated to interchange with the newly constructed I-81.

PA 374 runs south of the East Branch Tunkhannock Creek and comes to a partial cloverleaf interchange with I-81.

Past this interchange, the road heads northeast through more wooded areas with some residences, crossing into Clifford Township.

The route runs through areas of fields and woods with a few homes, coming to an intersection with PA 106 in Royal.

[3][4] The road runs through more farms and woods with some residences, passing to the north of Elk Mountain Ski Area.

The route turns north onto Lyon Street and passing through more rural areas.

This turnpike was planned to run between Damascus Mills and the summit of Moosic Mountain.