PA 463 runs through the northern suburbs of Philadelphia and passes through the towns of Hatfield, Montgomeryville, and Horsham.

The route continues into residential areas with a few businesses and enters the borough of Hatfield, where it becomes West Broad Street.

Here, PA 463 turns to the southeast on South Main Street and passes more residential and commercial development, crossing the Liberty Bell Trail and the Bethlehem Line, a railroad line that is owned by SEPTA and operated by the Pennsylvania Northeastern Railroad, at-grade.

The route crosses SEPTA's Lansdale/Doylestown Line at-grade southwest of the Fortuna station and intersects Broad Street in a commercial area.

[3][4] Heading past more homes, PA 463 enters Montgomery Township at the Line Street intersection.

[3][4] Upon crossing Lower State Road, PA 463 leaves the North Penn Valley region and fully enters Horsham Township, becoming a three-lane road with a center left-turn lane as it heads past housing subdivisions.

The route loses the turning lane and continues southeast to an intersection with PA 152 in the village of Prospectville.

At this point, PA 463 heads between the Biddle Air National Guard Base to the northeast and homes and businesses to the southwest, intersecting Norristown Road.

The route reaches the edge of the air station property at the Maple Avenue junction.