The route heads through a mix of suburban and rural areas of northern Montgomery County as a two-lane road, passing through Harleysville, before coming to an interchange with I-476 (Pennsylvania Turnpike Northeast Extension) in Kulpsville.

From this point, PA 63 continues through predominantly suburban areas of eastern Montgomery County as a two- to four-lane road, passing through Lansdale, Maple Glen, Willow Grove, and Huntingdon Valley.

Plans to extend Woodhaven Road northwest through the rest of Northeast Philadelphia remain, but have been on hold due to community opposition and financial constraints.

[3] The route crosses over the East Branch Perkiomen Creek before entering Lower Salford Township at the intersection with Morwood Road.

[4] In Towamencin Township, PA 63 widens to four lanes and is called Sumneytown Pike again, passing woods and development before reaching the Lansdale interchange with I-476 (Pennsylvania Turnpike Northeast Extension).

Along this stretch, the route passes southeast of Dock Mennonite Academy before crossing Allentown Road.

[3] At a crossing of Wissahickon Creek, PA 63 forms the border between Lansdale to the northeast and Upper Gwynedd Township to the southwest.

The route becomes a two-lane undivided road as it heads between business parks to the northeast and farms and woods to the southwest ahead of a junction with US 202 Bus.

[3][4] PA 63 turns into a four-lane divided highway that soon becomes undivided as it crosses over the Pennsylvania Turnpike (I-276) and Norfolk Southern's Morrisville Line before heading into a mix of residential and commercial areas as a five-lane road again.

The road enters business areas, becoming a divided highway again as it passes to the northeast of the Willow Grove Park Mall.

The route passes a mix of homes and businesses as it comes to an intersection with PA 611 (Old York Road).

Upon intersecting PA 232 (Huntingdon Pike) in the community of Bethayres, the route becomes Philmont Avenue and narrows back to two lanes.

PA 63 turns south-southeast onto Red Lion Road and crosses SEPTA's West Trenton Line at-grade as it continues through wooded residential subdivisions, making a curve to the southeast and intersecting Pine Road before heading into the city of Philadelphia in Philadelphia County.

[3][4] PA 63 enters the Northeast Philadelphia section of the city a short distance past the Pine Road intersection.

PA 63 widens into a four-lane divided highway and passes between a former golf course (site of the former Budd Company Red Lion plant) to the north and homes and industrial developments to the south.

East of PA 532, the route passes over CSX's Trenton Subdivision railroad line and comes to an intersection with US 1 (Roosevelt Boulevard).

This interchange also has access to the park and ride lot at the Cornwells Heights station on Amtrak's Northeast Corridor and SEPTA's Trenton Line.

[17] The PA 63 freeway was at one time proposed to continue northwest from Northeast Philadelphia to the Pennsylvania Turnpike (I-276) in Southampton.

[15] Meanwhile, plans still existed to extend Woodhaven Road from Evans Street to the Montgomery County border at Philmont Avenue.

This extension had been approved by the Federal Highway Administration in 1968 and the Pennsylvania Department of Transportation (PennDOT) had torn down 28 homes in the Somerton neighborhood in order to build the road.

[19] However, Lower Moreland Township officials again voiced their opposition that the extension would increase traffic on area roads.

[21] Despite this, plans for extending Woodhaven Road resurfaced in 2001 when local officials began discussing the extension with PennDOT.

[23] In addition, the project also calls for replacing the weight-restricted Byberry Road bridge over a CSX rail line.

[24] After putting the Woodhaven Road project on hold due to budget issues, PennDOT brought it back again as a parkway that is to continue west to PA 532, with an estimated cost of $30 million.

The current Woodhaven Road extension plan continues to face opposition from area residents who fear increased traffic.