PA 472 runs through a mix of farmland and woodland with some homes, turning west and passing through the community of Peacedale.

PA 472 continues northwest into East Nottingham Township and passes through rural land with mixed residential subdivisions.

The road curves west and enters the borough of Oxford, where it becomes Market Street and is lined with homes.

The road turns west and heads through residential areas with some farm fields, becoming Lancaster Pike and reaching an interchange with the US 1 freeway.

[2][4] At this point, the route enters the Pennsylvania Dutch Country of eastern Lancaster County, which is home to many Amish farms.

Here, the route turns west-northwest through more rural land with some development, crossing the West Branch Octoraro Creek.

The road continues into the borough of Quarryville and becomes South Lime Street, passing homes and some businesses.