The business route begins at US 322 northwest of the borough and heads southeast, entering West Chester on Hannum Avenue.

was designated PA 5 heading northwest of West Chester and US 122/PA 29 (later US 202) along High Street.

crosses into the borough of West Chester and comes to an intersection with the eastern terminus of PA 162 before the name changes to Hannum Avenue.

The route curves east past homes and businesses before it splits into a one-way pair.

follows Market and Chestnut streets northeast through the commercial downtown of West Chester.

West Market Street passes between the Chester County Justice Center to the north and SEPTA's West Chester Transportation Center and a parking garage to the south between New and Darlington streets.

At the northwest corner of High and Market streets is the historic Chester County Courthouse.

The route leaves the downtown area and continues past a mix of homes and businesses.

The road intersects the northern terminus of PA 52 at Price Street and runs southeast through the West Chester University of Pennsylvania campus.

The route curves south into wooded neighborhoods and loses the center turn lane.

[9] In 1957, US 322 was routed onto a limited-access bypass of West Chester to the north and east.

[10][11] By 1970, US 202 was routed to bypass West Chester along with US 322, removing the concurrency with US 322 Bus.