The route passes through developed areas in Northeast Philadelphia before heading north through suburban Bucks County, serving Feasterville, Holland, and Newtown before coming to Washington Crossing.

PA 532 crosses Grant Avenue and continues through areas of homes and businesses in the Bustleton neighborhood, curving north and coming to a bridge over CSX's Trenton Subdivision railroad line.

The route passes to the west of George Washington High School and intersects Verree Road as it continues through more developed areas, heading northeast into the Somerton neighborhood.

The route crosses Philmont Avenue and curves northeast, reaching an intersection with County Line Road.

The road comes to a bridge over the Pennsylvania Turnpike (Interstate 276) and continues to an intersection with PA 132 in Feasterville.

The road enters Northampton Township and passes under Norfolk Southern's Morrisville Line before heading past businesses in the community of Holland.

PA 532 passes through areas of wooded residential subdivisions, crossing Pine Run and heading to the east of Holland Middle School.

The roadway passes over an access road to Council Rock High School North before it heads to the east of Tyler State Park, curving to the northwest.

At the entrance to the park, PA 413/PA 532 turn northeast to remain on the Newtown Bypass while Swamp Road heads to the northwest.

[2][4] At this point, PA 532 turns north and runs along Washington Crossing Road, passing through a mix of woods and residential neighborhoods.

The route heads into a mix of fields and woodland with some residences, crossing into Lower Makefield Township.

The road curves northeast and runs through more areas of farms and woods with occasional homes, crossing Houghs Creek.