It is a major arterial road in central and northern Bucks County as it connects several communities including Quakertown, Dublin, and Doylestown.

The road passes a mix of homes and businesses before continuing into residential areas past the Main Street intersection.

The route enters the commercial downtown of Quakertown, where it splits into a one-way pair with two lanes in each direction.

PA 313 turns into a two-way, two-lane undivided road again and has a grade crossing with the Bethlehem Line, a railroad line that is owned by SEPTA and operated by the East Penn Railroad, north of the former Quakertown station, becoming East Broad Street and coming to an intersection with the western terminus of PA 212.

PA 313 continues near more residences with some businesses, making a turn to the east and leaving Quakertown for Richland Township.

Here, the route becomes Doylestown Pike and heads southeast through areas of fields and woods with some homes, crossing Morgan Creek.

The road passes to the southwest of the state park and continues through a mix of farm fields and woods with occasional residences, crossing Threemile Run.

The route passes more businesses as a five-lane road with a center left-turn lane, becoming the border between Buckingham Township to the northeast and Doylestown Township to the southwest before crossing North Easton Road/North Main Street, with North Easton Road providing access to northbound PA 611 and from southbound PA 611.

Past the Old Easton Road intersection a short distance later, the road narrows to two lanes and runs along the line between Buckingham Township to the northeast and Doylestown to the southwest, passing homes and businesses before running between farm fields to the northeast and Fonthill County Park to the southwest, which contains the Fonthill Museum and the Moravian Pottery and Tile Works.

Following this intersection, PA 313 forms the border between Buckingham Township to the northeast and Doylestown Township to the southwest, passing through a mix of woods and residential subdivisions before it reaches its eastern terminus at an intersection with PA 263 (York Road) in the community of Furlong.

Past this intersection, Swamp Road continues southeast along unsigned quadrant routes toward the borough of Newtown.

PA 113 split from Swamp Road and followed present-day Old Dublin Pike to US 611 (Main Street) in Doylestown, where it turned south for a concurrency.