From Willow Grove to Buckingham, PA 263 runs mostly through suburban areas as a four-lane road, passing through Hatboro, Warminster, and Jamison.

When Pennsylvania designated its state highways, PA 263 was assigned to its current alignment between Willow Grove and Centre Bridge in 1928.

[3] At this point, the route crosses the Pennypack Creek and heads into downtown Hatboro as a three-lane road with a center left-turn lane.

[5] In Warminster Township, the route turns into a five-lane road with a center left-turn lane and passes several businesses as it comes to the PA 132 (Street Road) junction, where it becomes into a four-lane divided highway that heads to the west of Archbishop Wood Catholic High School.

[4][5] PA 263 gains a center left-turn lane again as it continues north through more residential areas with a few businesses.

[5] At the junction with Bristol Road in the community of Hartsville, PA 263 enters Warwick Township and becomes a four-lane undivided highway as it turns north and runs through wooded areas with some homes, briefly becoming a divided highway as it passes over Creek Road and Little Neshaminy Creek on a bridge.

The route passes near residential and commercial development as it regains a center left-turn lane, reaching an intersection with Almshouse Road in the community of Jamison.

[4][5] After Almshouse Road, PA 263 continues north through business areas before heading past residential development, passing to the east of the Middle Bucks Institute of Technology.

[4] The route turns back into a divided highway as it crosses over the Neshaminy Creek in the community of Bridge Valley and regains a center left-turn lane as it passes through areas of woodland and homes.

[5] In Buckingham Township, PA 263 becomes a four-lane undivided road and passes a mix of farmland and homes, with a stretch of divided highway around the intersection with Heritage Center Drive, as it comes to the community of Furlong.

[4][5] PA 263 narrows to two lanes past this intersection and comes to a junction with US 202 a short distance later, where it forms a concurrency with US 202.

The two routes run along a two-lane undivided road that heads through fields and woodland with some development, passing through the community of Holicong and crossing Lahaska Creek.

The project rebuilt the concrete road and improved several intersections along this stretch, along with rehabilitating bridges and installing new signs, signals, pavement markings, and guardrails.