Unusually, PA 780 was used for two separate state highways for more than three decades, with a different route of the same number existing in Clinton County.

The route passes through wooded areas with some residential and commercial development, turning northeast onto 7th Street.

PA 780 heads east past more wooded areas of homes before winding south through a mix of fields and woods with some residences.

The route curves east and enters Upper Burrell Township, passing by the Penn State New Kensington university campus before continuing through forested areas with occasional residential development.

PA 780 passes through more forests as it heads into Washington Township and becomes North Washington Road, reaching its eastern terminus at PA 380.