The road passes through the residential community of Unionville, where it intersects the western terminus of PA 162.

The route continues through woodland with some fields and homes, crossing into Newlin Township.

The road heads through more farmland and woodland with some residences and enters Pocopson Township.

The road continues through rural areas with some homes and crosses the East Branch Brandywine Creek.

The route splits from Creek Road and continues northeast on West Miner Street as it heads through wooded areas with some homes.

At the Bradford Avenue intersection, the road crosses into the borough of West Chester and continues through residential areas.

The eastbound direction turns northwest onto South Brandywine Street before heading northeast onto West Market Street, entering the commercial downtown of West Chester and ending at the eastbound direction of US 322 Bus.