PA 162 enters Embreeville, where the road crosses an East Penn Railroad line at-grade and passes a few homes.

Leaving Embreeville, the road heads into forested areas and makes a turn to the east, continuing to parallel the creek.

As PA 162 moves away from the creek, it crosses into West Bradford Township and passes to the south of the closed Embreeville State Hospital before continuing past a mix of fields and woods as Telegraph Road.

The route bears east onto Strasburg Road and passes woodland and homes, running through the community of Marshallton.

The road gains a center left-turn lane and enters commercial areas as it crosses into the borough of West Chester at the Bradford Avenue intersection, coming to its eastern terminus at US 322 Bus.

[3] On September 1, 2021, the remnants of Hurricane Ida produced torrential rain over the region, causing severe flooding on the West Branch Brandywine Creek.