The northern half between US 45 Bypass in Mayfield and I-24 near Calvert City was redesignated as I-69 in July 2018.

The interchange with I-24 was reconstructed from a basic cloverleaf interchange to include a pair of direct high-speed connectors for I-69 through traffic continuing east concurrent with I-24, with the northernmost 1.67 miles (2.69 km) of the parkway becoming exit 51A-B (unsigned KY 2602) and facilitating access to westbound I-24 and US 62 for northbound traffic.

The southern half of the parkway from the Tennessee state line in Fulton to US 45 Bypass in Mayfield was redesignated as I-69 in December 2024.

On June 6, 2008, President George W. Bush signed HR 1195 (SAFETEA-LU Technical Corrections Act of 2008), reaffirming the I-69 designation for the Purchase Parkway and further authorizing Kentucky to sign the route as such with Federal Highway Administration (FHWA) approval.

The Julian M. Carroll Purchase Parkway from the junction with Interstate 24 west was legally designated to become part of I-69.