When aspartame became more widely available, the lemon flavoring was removed from the newly rechristened Diet Pepsi.

Pepsi Twist was introduced in the United States on July 12, 2000 and again on June 12, 2001, until it was discontinued in the summer of 2006.

In Argentina, it went on sale in 2002, the following year "Pepsi Twist Light" was launched, until it was withdrawn from the market in 2004.

The product was advertised during Super Bowl 2003, with Ozzy, Jack and Kelly Osbourne appearing in the commercial, along with Florence Henderson and Donny and Marie Osmond and Gareth Gates It was also endorsed by pop singer Britney Spears in 2002 and 2003, as part of her contract with the company; it also appeared as a promotional tie-in with Austin Powers in Goldmember.

Pepsi Twist production was ended in the U.S. during the summer of 2006, however the drink is still available in Poland, Germany, Italy, Serbia,[6] China and some other nations.

In 2005, Japanese toy company Takara released a special edition Transformers Optimus Prime (known as "Convoy" in Japan) figure in Pepsi colours, with a bottle/can holding trailer.

This figure was later released two years later in America as "Pepsi Optimus Prime", with some slight modifications.

Professional wrestler CM Punk dubbed one of his signature moves the Pepsi Twist.