A hundred years later, the Jamestown slum sees a series of attacks on women, all found with their throats bitten.
To avoid public panic, the police claims the deaths result from an outbreak of influenza, which is seen as one of the evils that came from genetic research.
Edgar has been developing a virus to make pregnant women give birth to vampires.
Edgar is also infected and insane, although the virus is taking effect more slowly due to his immune system.
Meanwhile, the government institutes a quarantine after the virus spreads throughout Jamestown, and humans riot outside the churches.
He warns Silus his career will be doomed if he ignores the "greater good" and breaches quarantine to save Lilly.
The Brother says that the infant is the first female vampire ever born, created by the virus: the first Perfect Creature.
Although Silus is branded a heretic and remains in hiding, he watches over Lilly as she takes care of the baby.
Jonathan Rhys-Meyers was originally cast as the villain Edgar, but was forced to leave the production due to other film commitments.
The Steampunk film was shot primarily around Dunedin and Oamaru in New Zealand's South Island.