Perfluorobutane can replace Halon 1301 in fire extinguishers,[4] as well as the gas component for newer generation microbubble ultrasound contrast agents.

Sonazoid[5] is one such microbubble formulation developed by Amersham Health that uses perfluorobutane for the gas core.

Due to its inert nature and high density, inhaling perfluorobutane makes one's voice deeper.

Caution is advised as heavier gases are difficult to breathe out and may cause inert gas asphyxiation.

If it is exposed to conditions of extreme heat from misuse, equipment failure, etc., toxic decomposition products including hydrogen fluoride can be produced.