Pertuis (French pronunciation: [pɛʁtɥi] ⓘ; Occitan: Pertús) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.

Located south of the Luberon, this town is also near Aix-en-Provence, a famous town.

Pertuis has existed since at least 981, while a castle was first built in the 12th century.

Pertuis has registered significant population growth since the 1960s, with a threefold increase during this period.

This Vaucluse geographical article is a stub.