After graduation and marriage he took a job as an illustrator and humorist with Hallmark Cards in Kansas City, where his son Philip was born.

He started his syndicated comic strip Travels with Farley while he and his second wife, Susan, lived on a house boat in Sausalito, on San Francisco Bay.

During this time his studio was in a pilot's cabin atop a ferry boat docked nearby[citation needed].

He had numerous commercial freelance clients, including the San Francisco Giants and Pet Food Express.

[citation needed] Frank announced his retirement for health reasons on September 7, 2007 [1] and died shortly thereafter in Bolinas, California.